- Brand Name: Olumiant;
- Active Ingredient: Baricitinib;
- Manufacturer: Eli Lilly.
Olumiant and its drug substance Baricitinib
Baricitinib is the approved active substance on the basis of which Olumiant was created. The medicine is produced in the form of tablets intended for oral intake.
Hospital studies have shown that patients with Covid feel much better when they take Olumiant. This applies to both patients with moderate disease severity and patients put on artificial pulmonary ventilation. In addition, there is evidence that the drug prevents the spread of coronavirus in the body.
Baricitinib works by reducing the activity of intracellular enzymes of the Janus kinase family. These enzymes perform a number of functions in the body, including participating in immune system reactions, namely in inflammatory processes.
By reducing the activity of these enzymes, Baricitinib helps reduce swelling, pain and stiffness in the joints. The drug slows the progression of rheumatoid arthritis and at the same time improves everyday symptoms of the disease.
Indications for use
Olumiant is approved for limited use in cases of moderately or critically ill patients with COVID-19. The main purposes of using the drug:
- Speeding up and facilitating the recovery process;
- Reducing the likelihood of switching a patient to artificial ventilation of lungs;
- Reducing the risk of complications for patients on artificial pulmonary ventilation.
Olumiant has been approved for the treatment of moderate to severe rheumatoid arthritis for adults when other anti-inflammatory drugs have been proven to be ineffective, cause allergies, or are contraindicated.
Main goals of treatment are:
- Relief of rheumatoid arthritis symptoms;
- Reducing the damaging effect of the disease on the joints;
- Slowing the progression of the disease.
Treatment regimens and dosages
The dosage regimen will depend on the reason for which you are prescribed Olumiant. A doctor will tell you how much and when to take the pills.
Dosage of Olumiant for emergency use for coronavirus according to the FDA, EMA and WHO recommendations:
- 4 mg once a day for patients over 9 years of age;
- 2 mg once a day for patients from 2 to 9 years of age.
The dose may be adjusted depending on the condition of the internal organs and the results of the blood test. The generally recommended duration of use for Olumiant tablets is up to 2 weeks. If you don't see any improvement after Olumiant, consult with your doctor or a pharmacist about changing the dosage.
Recommended doses of Olumiant for approved use are as follows:
- For adult patients (over 18 years of age), the usual starting dose is 4 mg once a day;
- Once satisfactory disease control has been achieved, the dose may be reduced to 2 mg once a day;
- Patients with serious infectious diseases, as well as those over 75 years of age, may be recommended to start with a dose of 2 mg once a day.
Recommendations for use
What you need to know when you use Olumiant:
- Take the pills before or after meals;
- Remember to take a dose at the same time every day;
- Do not chew or crush tablets before taking them.
Unless provided for by treatment, Olumiant should not be taken with other antirheumatic drugs in an attempt to increase the effect.
Avoid doubling or missing doses and other dosing errors. Take the missed dose as soon as possible. If you do not take a pill during the day, do not worry, but remember to take your next dose at the scheduled time.
Some medications are not suitable for people with certain diseases, and sometimes the medicine can only be used with extreme caution.
Before you start taking Olumiant, it is important for your doctor to know about:
- Any active or serious infection (such as tuberculosis);
- Allergies and allergic reactions;
- Increased cholesterol level;
- Problems with liver or kidney function.
Olumiant alone or in combination with other medicines can cause a condition in which blood clots form in the extremities, which can travel to the lungs.
Use of Olumiant during pregnancy
Do not take this medicine if you are pregnant or think that you might be pregnant. During the use of this medicine, there are risks of reduced fertility in women.
Possible side effects
Important information: Infections are the most common side effect of Olumiant. Due to the effect over the immune system, this drug increases the likelihood of contracting infections of a fungal, bacterial or viral origin.
Examples of other side effects:
- Skin rash;
- Increased levels of total creatine phosphokinase and its isoforms in plasma;
- Increase number of platelets in the blood;
- Increased levels of cholesterol;
- Cramps, pain, or discomfort in the abdomen.
Sometimes Olumiant can cause hypersensitivity reactions (allergies). You should contact your doctor for further instructions if you experience any of the following symptoms: Respiratory problems or swelling of the lips, tongue, throat, or face.
Baricitinib: interaction with other drugs
Olumiant may affect or be affected by some other medicines. Without first consulting a doctor, Olumiant should not usually be taken with the following drugs:
- Certolizumab Pegol;
If you have any doubts about the use of any of these or other medications, consult your doctor or a pharmacist.
Store in a dry place at a room temperature ranging from 20°C to 25°C. Don't store in the bathroom and any other places where temperature and humidity can vary significantly.
The best offer for Olumiant online on the market
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When you buy Olumiant online, you can quickly start treatment for COVID-19 or rheumatoid arthritis. We do not make diagnoses and we cannot tell you which medication or dosing regimen is best for you. For such questions, it would be better to consult a doctor.
We provide accurate and reliable health information that has been carefully reviewed and validated by our healthcare experts. So, you can always know about the effect of the medicine, dosing options, possible side effects and other important things.